维生素E（简称VE）作为抗氧化剂，广泛应用于动物生产。商品VE产品多为DL-α-生育酚醋酸酯（简称TOA），研究报道多。本试验以TOA为对照，选用新开发的商品VE产品——D-α-生育酚琥珀酸酯（简称TOS），研究其添加应用于不同油脂含量饲粮对肉鸡生长性能、肉质、抗氧化性能和脂类代谢的影响，并对其作用机制初步研究，为TOS在肉鸡生产中的进一步应用提供理论依据。研究包括三个实验： 试验一，研究不同油脂水平饲粮添加不同浓度生育酚酯对肉鸡生长性能及其器官发育的影响。试验采用2×4因子设计，选用1日龄AA肉鸡480只，随机分为8组，每组6重复，每个重复10只鸡，试验分为正常油脂饲粮组（N）和高脂饲粮组（H），这两种饲粮组内分别设4组，分别为NTOA（对照组）、NTOS1、NTOS2、NTOS3和HTOA、HTOS1、HTOS2、HTOS3，其中TOA、TOS1、TOS2和TOS3分别在饲粮中添加50 mg/kg TOA、50 mg/kg TOS、100 mg/kg TOS和150 mg/kg TOS，试验期42天。结果表明；高脂的添加能够显著提高肉鸡全期日增重及后期正常油脂组的日采食量（P<0.05），前期高脂TOS1组的日采食量显著高于对照（P<0.05），料重比在TOS2、TOS3组显著降低（P<0.05）；对于各器官指数，后期正常油脂组中TOS3的胸腺指数显著高于TOS2组（P<0.05），且后期高脂组中随着TOS添加量的增加，胸腺指数有提高的趋势，以TOS3组为佳；添加相同浓度的TOS效果优于TOA。 试验二：研究不同油脂水平饲粮添加不同浓度生育酚酯对肉质、抗氧化功能的影响，检测MDA浓度、SOD、CAT活性等以研究抗氧化机制。试验设计同试验一。结果表明：随着浓度的增加生育酚在肝脏中的沉积有显著提高（P<0.05），TOS的添加能够提高肉鸡血清及肝脏中VE的沉积；高脂组中，与对照组相比，TOS3组血清中MDA的浓度显著降低（P<0.05），TOS2、TOS3组血清中GSH-PX的浓度显著提高（P<0.05），证明TOS的添加能够清除脂质过氧化的影响，与低脂各组相比，高脂组的CAT活性均显著提高（P<0.05）。与TOS1相比，后期TOS2、TOS3红色度显著提高（P<0.05）。 试验三：研究不同油脂水平饲粮添加不同浓度生育酚酯对脂类代谢的影响。通过对脂质的沉积及脂代谢酶的检测进行研究。试验设计同试验一。结果表明：正常油脂组中，后期添加TOS能够显著降低血清中TG浓度（P<0.05），前期各TOS添加组的TC随着其浓度增加而降低（P>0.05），正常油脂组TOS2、TOS3组肝脏的苹果酸脱氢酶活性低于TOS1组，TOS2组；高脂组中，后期的的TG随着TOS浓度增加而降低。 综上所述，高油脂的添加能够降低料重比，增加平均日采食量及平均日增重，并显著改善肉鸡的生产性能，但同时也会增加血液及组织中脂质的沉积；随着日粮中TOS的添加，肉鸡的生产性能显著改善，能促进免疫器官胸腺的发育，且以100mg/kgTOS添加量效果最佳，且同水平添加的TOS和TOA相比，TOS的效果优于TOA；TOS的添加能够提高肉鸡血清及肝脏中VE的沉积，提高肉鸡抗氧化能力及肉产品的氧化稳定性，提高肉色和肌肉嫩度，改善肉品质；TOS的添加能够一定程度上降低血清中总胆固醇及总甘油三酯的浓度，并通过调节加速脂肪分解代谢及减少脂肪合成的酶来来调控脂类代谢，减少脂肪沉积。

The objective of the study was to investigate the effects of supplementing different levels fat diets with D-α-tocopherol succinate (D-α-TOS) and on growth performance, antioxidant properties and lipid metabolism in broilers when compeared with DL-α-tocopherol acetate (DL-α-TOA) as comparison. The study aimed to supply experimental basis for research of lipidmeatbolism and sceintific application of TOS in poultry production. The study consists of 3 experiments and the results were stated as follows: The first experiment was designed to evaluate the effects of TOS with different levels on growth performance, development of organs in broilers.Four hundred and eighty one-day-old Arbor Acres broilers were chosen and randomly distributed into 8 groups with 6 replicates of 10 chickens each, using 2×4 factorial design: two levels fat (hign fat diet and normal fat diet), including the following groups: NTOA(control group), NTOS1,NTOS2,NTOS3 ,HTOA,HTOS1,HTOS2,HTOS3(respectively added with 50mg/kg TOA, 50mg/kg TOS, 100mg/kgTOS, 150mg/kgTOS). The trial consisted of two periods: earlier stage (0-21days) and later stage (22-42days). The results showed that (1) The addition of TOS resulted in significantly higher daily gain and daily feed intake and lower F/G of those normal-fat-diet groups(P<0.05), in earlier stage of high-fat-diet groups, comparing to TOA group, daily feed intake of TOS groups have been significantly increased, while F/G been decreased(P<0.05); (2)In later stage, comparing with TOS2 in normal fat diet, thymus index of TOS3 was significantly higher(P<0.05), and that increased with the supplement of TOS, TOS3 showed the best; (3)The effect on growth performance of TOS was better than that of TOA at the same level. The second experiment was conducted to investigate the effects of TOS with different dose on antioxidant properties and meat quality. and malondialdehyde (MDA) content, superoxide dismutase(SOD) and CAT activity were determined to investigate the antioxidant mechanism. Treatments were the same as the first experinent. The results showed that: addition of TOS can exert significant effect on VE accumulation in liver(P<0.05); Compared with the control group, the MDA of TOS3, GSH-Px of TOS2 and TOS3 (both in high-fat-diet groups)were respectively reduced and increased, suggesting that the addition of TOS may to some extent eliminate the effect of lipid peroxidation. The activity of CAT in high fat diet were literaly higher than those in its corresponding normal fat diet(P<0.05). The red colour of thigh muscle of TOS2 and TOS3 were sinificantly higher than that of TOS1(P<0.05). In the third experiment, the effect of TOS with different dose on lipidmetabolism was studied by testing the accumulation of TC,TG,HDL,LDL,NEFA and kinds of lipidmetabolism enzymes. Treatments were the same as the first experinent. The results showed that: in later stage, increasing the levels of TOS may significantly decreased the TG of normal-fat-diet groups in broiler blood (P<0.05). Data showed that TC of earlier stage in normal-fat-diet groups, TG of later stage in high-fat-diet groups, were decreased with the enhancive dosage of TOS though not significantly (P<0.05). In normal-fat-diet groups, the values of MDH in TOS2 and TOS3 were reduced by the addition of TOS but not significantly with the comparison of TOS1,and the level of TG decreased with the addition of TOS. The results indicated that addition of high can increase the efficiency of feed, increase average feed intake and average daily gain, meanwhile increase the accumulation of lipid in both blood and issue; With the supplement of TOS, growth performance and development of immune organ thymus were improved, and TOS2 showed the best of the groups; 100 mg/kg dietary TOS supplementation may to the maximum enhance the production and properties of resisting peroxidation, reduce the level of lipid in blood and the accumulation of fat, the effect of TOS is better than that of TOA with the same addition. The effect on growth performance of TOS was better than that of TOA at the same level. TOS can increase the level of VE in both blood and liver, enhancing antioxidant properties of broilers and its product, abolishing meat and its quality; Besides, TOS can to some extent decrease the level of TC and TG, affecting lipidmetabolism by modulating the enzymes, reduce the accumulation of lipid.